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Gastroenterology/Crohn's Disease

Crohn's Disease - Causes & Treatments of Crohn's Disease

The bacteria is aggressivly attacked by t-cells causing extensive damage to intestinal tissue. Additional factors are released from dying epithelial cells that amplify the overactive immune system.

The damage can be treated by specially modified bacterium.

The modified bacteria releases a signaling molecule which inhibits t-cell activation and causes the t-cell itself to release additional signalling molecules.

The overactive immune condition of the intestinal wall is stopped, and the bowel starts to heal.

References:

  1. Baumgart DC, Sandborn WJ (12 May 2007). "Inflammatory bowel disease: clinical aspects and established and evolving therapies.". The Lancet 369 (9573): 1641–57. doi:10.1016/S0140-6736(07)60751-X. PMID 17499606.
  2. VIB - Flanders Institute for Biotechnology, http://www.scientistsatwork.be/content/extras