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Gastroenterology/Ulcerative Colitis

Ulcerative Colitis - Mechanism of Disease

Ulcerative colitis is an inflammatory condition of the large intestine caused by an inappropriate immune response to a range of environmental, microbial and immune stimuli.

Inflammation of the lining of the large intestine occurs, and ulcers may develop on the surface of this lining.

Dysfunction of the immune system in the intestinal wall plays an important role in ulcerative colitis, which is characterized by the infiltration of immune cells, which release an array of inflammatory molecules including pro-inflammatory cytokines.


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