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Haematology/The Clotting Cascade (Factor 9)

The Clotting Cascade (Factor 9) - MOA

The characteristic phenotype in people with haemophilia is the bleeding tendency.

Bleeds can occur spontaneously, or as a result of trauma or surgery. In people with haemophilia B the level of factor 9 is low or missing, so it cannot bind with Factor 8 to activate Factor 10.

Without Factor 9, the rest of the clotting process cannot continue.