Neurology

Alzheimer’s Disease

Alzheimer's disease is an area of intense preclinical and clinical research. In this animated video, produced for Nature Neuroscience, we introduce the molecular, cellular and physiological mechanisms associated with the disease, highlighting some of the most recent advances in our understanding of the onset and progression of this devastating neurological condition. The video also illustrates current gaps in our scientific knowledge that will be important to address to generate effective treatments for the disease.

Parkinson’s Disease

Parkinson’s disease is the second most common neurodegenerative disorder and is associated with an array of motor and non-motor symptoms. This animation focuses on how neurons may become dysfunctional and die in Parkinson’s, and how the underlying pathology may develop. It also touches on current treatments and potential therapeutic strategies for the disease. We developed this animation for Nature Reviews Neuroscience and Nature Neuroscience and is freely available online thanks to support from Roche.

Migraine

This excerpt is from a 3D stereoscopic MOA animation explaining process of migraine attack.

Migraines begin when neurons in the brain start misfiring in response to internal or environmental triggers, releasing chemicals that cause blood vessels to swell and dilate. Pain receptors surrounding these vessels, transmit pain signals to the higher centres of the brain, and create the first sensation of pulsating headache pain.