Ophthalmology

Dry Eye Disease

Dry eye disease is a common condition that can have significant effects on patients’ lives due to persistent irritation and pain.

Dry eye disease is a common condition that can have significant effects on patients’ lives due to persistent irritation and pain. In dry eye disease the tear film is compromised, and the epithelial cells are dehydrated and lack osmotic balance. Tear hyperosmolarity damages the surface epithelium, causing tear film instability and hyperosmolarity of the ocular surface, further exacerbating the vicious cycle of disease.

Tear Film Lipid Enhancement

This is one of a series of animations created for Allergan's family of Optive products.

OPTIVE Plus uses novel lipid-enhancement technology to optimise delivery of lipid molecules to the tear film. Polysorbate 80 and the salt-sensitive polymer form a polymer capsule around castor oil and prevent separation. This results in homogeneous distribution throughout the solution meaning there is no need to shake the bottle before use.

When OPTIVE Plus is administered to the eye, the salt-sensitive polymer mixes with naturally occurring salts in the tear, allowing OPTIVE Plus’ polymer capsules to open up. This releases the castor oil so that it can quickly and efficiently supplement the lipid layer, where it helps to minimise tear evaporation and reduce the symptoms of lipid-deficient dry eye disease.